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The Division of Clinical Pharmacology
at the Johns Hopkins University School of Medicine is
part of both the Department
of Medicine and of the Department
of Pharmacology and Molecular Sciences. An endowment
made in 1971 by the Burroughs Wellcome Fund established
the Wellcome Professorship and the annual Sir
Henry Dale Lecture.
Past directors of the Division include Louis Lasagna whose
research on the quantitative measurement of pain and the
importance of the placebo were seminal; Pedro Cuatrecasas,
best known for his discovery of the insulin receptor;
and Paul Lietman whose deep interest in anti-infective
agents molded the careers of the current faculty. Since
2001 the Division has been directed by Theresa Shapiro,
whose interests include the discovery and development
of new treatments for malaria and other parasitic infections.
Research efforts of the current faculty
focus primarily on therapies for infectious diseases:
antibiotics, antiparasitics, antifungals, and antivirals.
Of particular interest are studies that translate laboratory
discoveries into clinical practice. Though each faculty
member has an individual research program, sometimes with
a substantial molecular laboratory component, all clinical
studies are conducted in the Division's Drug
Development Unit, often with support from the Division's
Analytical Laboratory,
and typically under the auspices of the NIH-sponsored
General
Clinical Research Center.
The Clinical Pharmacology faculty at Johns Hopkins teach
undergraduates, all four years of medical students, graduate
students in three Schools of the University, housestaff,
and peer physicians. Major teaching venues include second
and fourth year Pharmacology courses for the medical students
(330.600
Pharmacology and 250.604
Rational Therapeutics); the Graduate
Training Program in Clinical Investigation; 330.707 Graduate
Pharmacology; and 330.808 Principles of Clinical Pharmacology and 330.809 Analytical Methods in the Clinical Pharmacology. An important aspect of teaching
is the individual mentoring of young colleagues. Trainees
from the Division have risen to international leadership
positions in academia, industry, and federal agencies.
The Division of Clinical Pharmacology impacts directly
on patient care at the Johns Hopkins Hospital via the
office of the Hospital
Pharmacologist. This innovative mechanism brings a
scholarly approach to key policy decisions on rational
drug selection and usage in the hospital. |
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