Research Interests:
Molecular and clinical pharmacology of antiparasitic drugs; DNA topoisomerases as antiparasitic drug targets; structure-activity of synthetic antimalarial trioxanes

Selected Publications:
Shapiro TA, Ranasinha CD, Kumar N, and Barditch-Crovo P (1999) Prophylactic activity of atovaquone against Plasmodium falciparum in humans. Am J Trop Med Hyg 60: 831-836.

Shapiro TA, Fahey JW, Wade KL, Stephenson KK, and Talalay P (2001)  Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans.  Cancer Epidemiol Biomarkers Prev 10: 501-508.

Bodley AL, Chakraborty AK, Xie S, Burri C, Shapiro TA. (2003) An unusual type IB topoisomerase from African trypanosomes. Proc Natl Acad Sci USA. Jun 24; 100 (13) 7539-7544.

Kulikowicz T and Shapiro TA (2005) Distinct genes encode type II topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei.  J Biol Chem 281:3048-56.

Bakshi R and Shapiro TA (2004) RNA interference of Trypanosoma brucei topoisomerase IB: Both subunits are essential.  Mol Biochem Parasitol 136:249-55.

Paik I-H, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, and Posner GH (2006) Second generation, orally active, antimalarial artemisinin-derived trioxane dimers with high stability, efficacy and anticancer activity.  J Med Chem 49:2731-4.

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