Research Interests:
Understanding the mechanisms of drug cytotoxicity in trypanosomes and malaria parasites and identification of potential drug targets in these organisms; and many aspects of glycobiology and particularly the structure, synthesis and function of the carbohydrate moieties of glycoproteins.

Selected Publications:
Scocca J and Lee YC (1969) The composition and structure of the carbohydrate of pineapple stem bromelain. J Biol Chem. 244:4852-63.

Lee YC and Scocca JR (1972) A common structural unit in asparagine-oligosaccharides of several glycoproteins from different sources. J Biol Chem. 247:5753-8.

Thomas GH, Scocca J, Miller, CS and Reynolds LW (1989) Evidence for non-lysosomal storage of N-acetylneuraminic acid (sialic acid) in sialuria fibroblasts. Clin Gen. 36:242-9.

Scocca JR and Krag SS (1990) Sequence of a cDNA which specifies the uridine diphosphate-N-acetyl D-glucosamine: dolichol phosphate N-acetyl glucosamine-1 phosphate transferase from Chinese hamster ovary cells. J Biol Chem. 265:20621-6.

Scocca JR, Zou J and Krag SS (1995) Genomic organization and expression of hamster UDP-N-acetylglucosamine: dolichyl phosphate N-acetylglucosaminyl phosphoryl transferase. Glycobiology. 5:129-36.

Scocca JR and Krag SS (1997) Aspartic acid 252 and asparagine 185 are essential for activity of lipid N-acetylglucosaminylphosphate transferase. Glycobiology. 7:1181-91.

Return to Faculty Home