Research Interests:
Quantitative mass spectrometry via combined liquid chromatography-tandem mass spectrometry and applications to clinical and laboratory research; (1) pharmacokinetics and metabolism of agents employed for treatment of HIV/AIDS and other viral disease; (2) lipid molecular species: potential for newborn screening for leukodystrophies and roles as mediators of signal transduction in cells.

Selected Publications:
Giardiello, FM, Yang, VW, Hylind, LM, Krush, AJ, Petersen, GM, Trimbath, JD, Piantidosi, S, Garrett, E, Geiman, DE, Hubbard, WC, Offerhaus, GJ , Hamilton, SR. (2002) Primary chemoprevention of familial polyposis with sulindac. N Engl J Med 346: 1054-9.

Berdyshev, EV, Gorshkova, IA, Garcia, JGN, Natarajan, V and Hubbard, WC (2005) Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal Biochem 339: 129-136.

Petrache, I, Natarajan, V, Zhen, L, Medler, TR, Richter, AT, Cho, C, Hubbard, WC, Berdyshev, EV and Tuder, RM. (2005) Ceramide upregulation causes pulmonary cell apoptosis and emphysema. Nature Medicine 11:491-8.

Li, J, Thorne, LN, Punjabi, NM, Sun, C,-K., Schwartz, AR, Smith, PL, Marino, RL, Rodriguez, A, Hubbard, WC, O’Donnell, CP, and Polotsky, VY. (2005) Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 97: 698-706.

Hubbard, WC, Moser, AB, Tortorelli, S, Liu, A and Moser, H. (2006) Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: Preliminary findings. Molec Genet Metab, 89:185-7.

Berdyshev, E V, Gorshkova, IA, Usatyuk, P, Zhao, Y, Hubbard, W, and Natarajan, V. (2006) De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell Signaling, 18: 1779-92

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