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Charles Flexner, MD spacer
Edward J. Fuchs, PA-C, MBA
Associate Director, Drug Development Unit
Research Associate, Medicine

Johns Hopkins University
600 N. Wolfe Street, Harvey 502
Baltimore MD 21287-5554
Phone: 410-614-8762
Fax: 410-955-9708

Email: ejfuchs@jhmi.edu
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Interests:
Topical HIV microbicides, application of imaging technologies in clinical pharmacology, empirical assessment of clinical research ethics.

Selected Publications:
Fischl M, Parker C, Pettinelli C, Wulfsohn M, Hirsch M Collier A, Causey D, Ho M, Richman D, Fuchs E, Merigan T, Reichman R, Gold J, Steigbagel N, Leoung G, Rasheed S, Tsiatis A, and The AIDS Clinical Trials Group (1990) A randomized controlled trial of a reduced daily dose of zidovudine in patients with the Acquired Immunodeficiency Syndrome. N Engl J Med 323: 1004-9.

Hendrix, CW, Flexner C, MacFarland RT, Giandomenico C, Fuchs EJ, Redpath E, Bridger G, Henson GW (2000) Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Antimicrob Agents Chemother 44:1667-73.

Fuchs, E (2000) Improving performance in clinical trials. Research Practitioner Vol 1/3: 81-5.

Spivak J, Barnes D, Fuchs E, Quinn TC (1989) Serum Immunoreactive erythropoietin in HIV-infected patients. JAMA 261: 3104-7.

Hendrix CW, Wakeford J, Wire MB, Bigelow G, Cornell E, Christopher J, Fuchs E, Snidow J (2004) Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with amprenavir in opioid-dependent subjects. Pharmacotherapy 24:1110-21.

Fuchs EJ, Wahl R, Macura K, Leal J, Grohskopf L, Hendrix CW (2005) Imaging the distribution of a rectal microbicide gel and semen surrogate in the lower gastrointestinal tract. Clin Pharmacol Ther 77:P60.

Fuchs EJ, Lee LA, Torbenson MS, Parsons TL, Bakshi RP, Guidos AM, Wahl RL, Hendrix CW. Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission. J Infect Dis 2007, in press.



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