Interests:
Basic biology of parasitic protozoa, DNA topoisomerases as drug targets, pharmacokinetic-pharmacodynamic relationships of drugs, preclinical development of anti-infective agents

Selected Publications:
Bakshi RP, Galande S, Muniyappa K (2001) Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase. Crit Rev Biochem Mol Biol. 36:1-37.

Bakshi R, Galande S, Muniyappa K (2001) Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIalpha. J Biomol Struct Dyn. 18:749-60.

Bakshi RP, Galande S, Bali P, Dighe R, Muniyappa K (2001) Developmental and hormonal regulation of type II DNA topoisomerase in rat testis.
J Mol Endocrinol. 26:193-206.

Bakshi RP, Shapiro TA (2003) DNA topoisomerases as targets for antiprotozoal therapy. Mini Rev Med Chem. 3:597-608.

Bakshi RP, Shapiro TA (2004) RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential. Mol Biochem Parasitol. 136:249-55.

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