Darrell R. Abernethy, MD, PhD
Chief Science Officer
United States Pharmacopeia
Professor of Medicine, and Pharmacology and Molecular Science
Johns Hopkins University School of Medicine

Laboratory of Clinical Investigation
National Institute on Aging
NIH 5600 Nathan Shock Drive
Baltimore, MD 21224-6825
Phone: 410-558-8611
FAX: 410-558-8318

Email: abernethyd@grc.nia.nih.gov

Mager DE, Mascelli MA, Kleiman NS, Fitzgerald DJ, Abernethy DR (2003) Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty. J Pharmacol Exp Ther 307:969-976.

Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR (2004) Abciximab pharmacodynamic model using neural networks to integrate sources of patient variability. Clin Pharmacol Ther 75:60-69.

Kobrinsky E, Kepplinger KJF, Yu A, Harry JB, Kahr H, Romanin C, Abernethy DR, Soldatov NM (2004) Voltage-gated rearrangements associated with differential β subunit modulation of the L-type Ca²⁺ channel inactivation. Biophys J 87:844-857.

Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM (2004) New short splice variants of the human cardiac Cavbeta 2 subunit: Redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 279:46367-46372.

Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. (2005) Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca²⁺ ions. J Biol Chem 280:12474-85

Kobrinsky E, Mager DE, Bentil SA, Murata S, Abernethy DR, Soldatov NM. (2005) Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy. Biophys J 88:3625-34

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